通讯地址:北京市海淀区阜成路11号
obao欧宝娱乐 化学与材料学院
邮编:100048
电话:010-68984937
电子信箱:jinjianming@btbu.edu.cn
工作经历:
2012年至今obao欧宝娱乐 理学院教授;
2011-2012年云南民族大学化学与生物技术学院教授;
2010-2011年美国奥克拉荷马大学从事研究工作;
2009-2010年香港浸会大学生物系从事研究工作;
2002-2009年韩国首尔大学农学与生命科学学院从事研究工作;
1997-1999年中国科学院水生生物研究所助理研究员;
1993-1994年浙江永宁药业股份有限公司。
学历:
1999-2002年中国科学院昆明植物研究所植物化学专业,获理学博士学位;
1994-1997年武汉大学生命科学学院生物化学专业,获理学硕士学位;
1989-1993年武汉大学生命科学学院生物化学专业,获理学学士学位。
讲授课程:
天然产物化学;天然产物分离工程。
研究领域:
1、中草药提取物的精制和开发应用研究;
2、天然活性成分的高效生物转化研究;
3、天然活性成分的生物合成及其调控机制研究。
科研项目:
主持2项国家自然科学基金和1项北京市自然科学基金项目,参与1项科技部科技支撑项目和1项星火项目,与多个企业合作进行新产品研发和生产技术改造。
发表论文:
1.Jun Yao#, Yang He#, Nannan Su, Sakshibeedu R. Bharath, Yong Tao,Jian-Ming Jin*, Wei Chen*, Haiwei Song* and Shuang-Yan Tang*. Developing a highly efficient hydroxytyrosol whole-cell catalyst by de-bottlenecking rate-limiting steps.Nature Communications, 2020, 11: 1515.
2.Jun Yao#, Jing Li#, Dandan Xiong, Yuanyuan Qiu, Guizhi Shi,Jian-Ming Jin*, Yong Tao* and Shuang-Yan Tang*. Development of a highly efficient and specific L-theanine synthase.Applied Microbiology and Biotechnology, 2020, 140(8): 3417-3431.
3.Chaoning Liang, Xuanxuan Zhang, Jieyuan Wuc, Shanshan Mu, Zhe Wu,Jian-Ming Jin*and Shuang-Yan Tang*. Dynamic control of toxic natural product biosynthesis by an artificial regulatory circuit.Metabolic Engineering, 2020, 57: 239-246.
4.Wei Chen#, Jun Yao#, Jie Meng, Wenjing Han, Yong Tao, Yihua Chen, Yixin Guo, Guizhi Shi, Yang He,Jian-Ming Jin*and Shuang-Yan Tang*. Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis.Nature Communications, 2019, 10: 960.
5.Chen Wei, Zhang Xuanxuan, Xiong Dandan,Jin Jian-Ming*and Tang Shuang-Yan*. Engineering the effector specificity of regulatory proteins for the in vitro detection of biomarkers and pesticide residues.Applied Microbiology and Biotechnology, 2019, 103(7): 3205–3213.
6.Heng Li, Jing Li, Ruinan Jin, Wei Chen, Chaoning Liang, Jieyuan Wu,Jian-Ming Jin, Shuang-Yan Tang*. Towards the construction of high-quality mutagenesis libraries.Biotechnology Letter, 2018, 40: 1101–1107.
7.Heng Li, Wei Chen, Rui-Nan Jin,Jian-Ming Jin*, Shuang-Yan Tang*. Biosensor‑aided high‑throughput screening of hyper‑producing cells for malonyl‑CoA‑derived products.Microbial Cell Factories, 2017,16: 187.
8.Heng Li, Chaoning Liang, Wei Chen,Jian-Ming Jin*, Shuang-Yan Tang*, Yong Tao. Monitoring in vivo metabolic flux with a designed whole-cell metabolite biosensor of shikimic acid.Biosensors and Bioelectronics, 2017,98: 457–465.
9.Jieyuan Wu, Peixia Jiang, Wei Chen, Dandan Xiong, Linglan Huang, Junying Jia, Yuanyuan Chen,Jian-Ming Jin*, Shuang-Yan Tang*. Design and application of a lactulose biosensor.Scientific Reports, 2017,7: 45994.
10.Dandan Xiong, Shikun Lua, Jieyuan Wu, Chaoning Liang, Wei Wang, Wenzhao Wang,Jian-Ming Jin*, Shuang-Yan Tang*.Improving key enzyme activity in phenylpropanoid pathway with a designed biosensor.Metabolic Engineering, 2017,40: 115-123.
11.You-Hai Li, Wen-Jin Han, Xi-Wu Gui, Tao Wei, Shuang-Yan Tang,Jian-Ming Jin*. Putative nonribosomal peptide synthetase and cytochrome P450 genes responsible for tentoxin biosynthesis inAlternaria alternataZJ33.Toxins, 2016,8: 234.
12.Chaoning Liang, Yi Zhang, Yan Jia, Wenzhao Wang, Youhai Li, Shikun Lu,Jian-Ming Jin*, Shuang-Yan Tang*. Engineering a carbohydrate-processing transglycosidase into glycosyltransferase for natural product glycodiversification.Scientific Reports, 2016,6: 21051.
13.Lin Zhu, Zhe Wu,Jian-Ming Jin,Shuang-Yan Tang*. Directed evolution of leucine dehydrogenase for improved efficiency of l-tert-leucine synthesis.Applied Microbiology and Biotechnology, 2016,100: 5805-5813.
14.文海丽,许丽,李有海,韩文敬,金建明*。三七总皂苷酶水解产物成分研究。天然产物研究与开发,2018,30:1565-1568。
15.韩文敬,陆仕坤,文海丽,许丽,金建明*,唐双焱。人参果梗的化学成分研究。中草药,2018,49(8): 1571-1580。